Welcome to the Zhuang Group at the University of Delaware


Our research program is highly interdisciplinary, encompassing chemistry, biology and medicine. Our current efforts are directed toward understanding the chemistry and biology of protein post-translational modification (PTM) by ubiquitin (Ub) and eukaryotic DNA damage response, which are closely related to human cancer. We focus on the function, structure and regulation of enzymes and protein complexes involved in reversible protein ubiquitylation and DNA translesion synthesis. The current projects include the regulation and inhibition of deubiquitinase (DUB) complex; developing chemical approaches for protein ubiquitylation; and molecular mechanism of DNA translesion synthesis. We investigate these problems at a molecular level by employing a broad spectrum of chemical, structural, and biological approaches.



Join Us

We are looking for talented graduate students and postdoctoral fellows with interests and expertise in biochemistry, organic synthesis, structural biology, and molecular & cell biology. Please contact us at This email address is being protected from spambots. You need JavaScript enabled to view it. or (302) 831-8940 if you are interested in joining our research group.